Synthesis of Bis-pyridyl-3-methylamine (A potential anti-hypertensive agent)

Abstract

Bis Pyridyl – 3 – Methyl amine was synthesized. It was amino compound which could be screened for its for its bio-activity. This is against thebackdrop that certain amines had positive actions as anti-hypertensive agents especially their roles as anti-depressant and inhibitors of monoamine oxidase (MAOI). The starting material was pyridine 3-carboxylic acid which was converted to pyridine -3- carbonyl chloride, Bis pyridine -3- carboxylic amine and finally to the desired product. The reagent for the conversions were thionyl chloride, concentrated ammonia and Clemenson reduction reactions respectively