Investigation of the Effect of Aqueous Mistletoe Leaf Extract on Glucose and Cholesterol Levels in Alloxan-Induced Diabetic Rabbits.

Abstract

Aqueous leaf extract of the mistletoe was investigated for hypoglycemia and hypocholesterolaemic effect in diabetic rabbits. Diabetes was induced in rabbits in groups I - II by a single intraperiteal injection of alloxan monohydrate at 100mg/kg bodyweight. Following confirmation of hyperglycaemia, groups I and II were with the extract at 1.32 and 2.64 g/kg bodyweight for three consecutive days. After the last treatment, rabbits were fasted for 12 hours and bled at 0, 2, 4, 6 and 24 hours. Serum glucose levels were determine by the glucose oxidase method and cholesterol by Liebermann-Buchard method. The results showed statistically significant decrease (P,0.05) in glucose levels at 0 and 2 hours , though there was increase at 6 and 24 hours. Cholesterol levels decreased at 0, 2, 4, and 24 hours, but not significantly (P>0.05) when compared to control group III. Aqueous leaf extract of mistletoe (an epiphyte of lemon trees) may be recommended for frequent consumption in the management of insulin - dependent diabetes.