Effect of Sesame Seeds on Biochemical and Haematological Parameters in Wistar Rat

Abstract

Sesame seeds and its components have the tendency to provide various health benefits and have been proven to exhibit anticancer, antioxidant, and cholesterol lowering properties. This research aims to evaluate the effect of Sesame seed on biochemical composition and hematological parameters in wistar rats. Animal study was performed by feeding wistar rat with specific ration of formulated sesame feed for twenty-one (21) days. Biochemical, and hematological analyses were carried out using standard methods. The significant (p<0.05) difference were recorded in all the parameters across the groups in the biochemical component of the kidney with creatine value ranged from (5.47±0.31-7.53±0.43) from group B and D, Urea ranged from ( 20.84±1.36- 30.44±1.76) from group C and Control, Uric acid, (4.49±0.25-5.13±0.30) from group C and Control, Na, (143.19±276-157.23±2.47) from group B and Control, K, (7.04±0.29-8.21±0.36) from group D and C, Bicarbonate ( 22.02±0.94-28.00±1.42). Significant (P<0.05) were recorded in the biochemical component of Liver in the following parameters (TP, ALB, ALP, ALT, AST, CHO, LDL, HDL, TRIGS and TB. There was significant (P<0.05) difference in haematological parameters like HB with the value ranged, (7.30±0.52-9.03±0.29), and RBCS (6.96±0.37- 8.37±0.39). Sesame has ability to ameliorate and improve some biochemical and haematological parameters in rat which could make a good candidate for diet supplementation especially in certain disease conditions.