ASSESSMENT OF SOME ENZYMES AND HAEMATOLOGICAL PARAMETERS IN MALARIA PATIENTS, RESIDENT IN MINNA AND ITS ENVIRONS

Abstract

The activities of some serum enzymes which included serum glutamate pyruvate transaminase (SGPT), serum glutamate oxalate transaminase (SGOT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and glucose-6-phosphate dehydrogenase (G-6-PD) with haematological parameter packed cell volume (PCV) and Haemoglobin (HB) were assayed in one hundred and one malaria patients attending the outpatient unit of the General Hospital Minna, Nigeria. The results obtained indicated that the activities of serum glutamate pyruvate transaminase (36.9±2.1 iu/L), serum glutamate oxalate transaminase (35.0±2.2 iu/L), alkaline phosphatase (45.7±1.7 iu/L) and glucose-6-phosphate dehydrogenase (O.012±O.008 iu/L) in malaria patients were significantly difference (P<O.05) from the values in controls SGPT (27.50±2.6 iu/L), SGOT (21.9±1.3 iu/L), alkaline phosphatase (35.5±2.5 iu/L) and G-6-PD (O.015±O.009). lactate dehydrogenase activities were comparable between the patients and healthy subjects. The results from males alone, exhibited a similar trend as that for the general population above i.e significant (P<O.05) variations in SGPT, SGOT, ALP and G-6-PD. lactate dehydrogenase actiivites were however comparable between male patients and male controls. Comparison of enzymes values between females alone demonstrated significant difference (P<O.05) in the activities of SGPT, SGOT, LDH and 'G-6-PD but not ALP. Values for females and males showed that only SGOT and SGPT were not significant (P>O.05). The haematological parameters PCV and HB were generally higher in the controls as compared with malaria patients and this was irrespective of the gender. Therefore it is concluded that enzymes activities are mostly elevated in malaria patients and red blood cell are also destroyed depending on the level of parasitamea .